PhoreMost enters multi-target collaboration with targeted protein degradation leader Arvinas

28th October 2022

PhoreMost to deploy its SITESEEKER® Targeted Protein Degradation platform to enable drug discovery against multiple therapeutic targets

Cambridge, UK, 28th October 2022: PhoreMost Ltd., the UK-based biopharmaceutical company dedicated to ‘Drugging the Undruggable®’ disease targets, today announced it has entered into a multi-target collaboration with Arvinas, an industry leader in targeted protein degradation (TPD). Under the terms of the agreement, PhoreMost will receive research funding and will be eligible for pre-clinical, clinical, and commercial milestones.

PhoreMost will deploy its in-house expertise and next-generation phenotypic screening platform, SITESEEKER®, toward multiple high-value therapeutic targets. The output from SITESEEKER screening campaigns will be used to drive degrader drug discovery in oncology and neurodegeneration using Arvinas’s proprietary PROTAC® Discovery Engine platform.

The SITESEEKER platform is based on PhoreMost’s core proprietary ‘Protein Interference’ (PROTEINi®) technology. PhoreMost probes the entire proteome in a live cell environment for novel druggable targets linked to any chosen disease, using the vast shape diversity of proprietary miniprotein libraries. SITESEEKER systematically unmasks new and unanticipated druggable sites across the entire human proteome, directly linking them to useful therapeutic functions.

This is another exciting collaboration for our team, and we are delighted to be working together with the leaders in the targeted protein degradation space. For Arvinas to recognise the potential of SITESEEKER to help deliver significant therapeutic breakthroughs is further testament to the progress we have made in developing our platform.
Dr. Neil Torbett, CEO of PhoreMost, said

Identifying new protein binders is imperative for Arvinas as we expand the capabilities of our PROTAC platform. We are excited to begin this collaboration to leverage PhoreMost's phenotypic screening platform and to make continued progress towards degrading undrugged targets across multiple complex diseases.
Dr. Angela Cacace, Senior Vice President of Neuroscience & Platform Biology at Arvinas, said