Pioneering technology

Conventional methods for discovering new drug targets often result in many proteins being intractable.

Our novel SITESEEKER® platform rapidly identifies unexpected or “cryptic” druggable sites that can’t be readily seen using conventional technologies. SITESEEKER uses PROTEINi® (protein interference) libraries which exploit the shape diversity inherent in proteins in the search for novel drug targets.

PROTEINi® libraries

PROTEINi® libraries are very large collections of shapes that can directly find new ‘hand-in-glove’ target-interaction sites throughout the whole proteome.

The technology utilises diverse libraries of small, self-folding, three-dimensional peptide "shapes", which are expressed in live cells and, much like small molecules, interfere and engage with available pockets on target proteins on a proteome-wide scale. Using pooled phenotypic screening formats we rapidly identify key peptide-target interactions of therapeutic interest, which we then use as a basis to design small-molecule inhibitors.

PROTEINi are small fragments of larger proteins, which retain a 3D structure that can rationally find a diversity of new 3D binding sites across the entire proteome. This is performed in a live-cell “phenotypic” setting so that a useful disease readout can be directly and simultaneously defined.

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